I would actually have Burrow just hand off a lot. I know, I know, Joe wants to throw, Zac wants to throw, but the cold hard fact is that not being able to run the ball has been a big part of opening day losses the last two years. I would also make stopping the run a preseason point of emphasis for the defense, that's been an equally major problem.
Last year, future hall of famer (checks notes) Rhamondre Stevenson gashed the Bengals for 120 yards on 25 carries. That was 15% of his total yards for the season! That let the Pats play keep-away all game. meanwhile Moss and Brown managed just 55 yards on 12 combined carries.
The year before that, Mixon got 13 carries for 56 years, while Chubb and Ford combined for 142 and Watson threw in 45 more on the ground.
If we go up to Cleveland and Chase is getting stuffed while Ford and Judkins run wild we will lose again, even though the Browns' QB will probably be some random fan who wins a pregame punt, pass and kick contest.