Imho, the strongest argument for cashing in a premium pick on a running back is that the best way to protect Burrow is a top-tier running game. Having a guy who can just take a handoff and rip off 10-20 yards every time they try to come after Joe would do wonders for his sack numbers. And the best way to make sure guys like Volson and Ford don't choke in pass protection is to not ask them to pass protect as much, just plow the road.
Of course, that raises the question of why you need to pay a combined $500 million for a franchise QB and two No. 1 wideouts, but hey, water under the bridge, right?
To be clear, I don't really think this is something they are considering. Maybe there's a verrrrrrrrrry slim chance that they take the plunge if Jeanty slips to 17. Otherwise I think round 4 is the earliest we go RB. But it's fun to think about.